Cathelicidin LL-37 bloodstream surveillance is down regulated during septic shock.

Autor: Barbeiro DF; Emergency Medicine Department, University of São Paulo, Brazil., Barbeiro HV, Zampieri FG, César Machado MC, Torggler Filho F, Gomes Cunha DM, Goulart AC, Velasco IT, Monteiro da Cruz Neto L, Possolo de Souza H, Pinheiro da Silva F
Jazyk: angličtina
Zdroj: Microbes and infection [Microbes Infect] 2013 May; Vol. 15 (5), pp. 342-6. Date of Electronic Publication: 2013 Jan 14.
DOI: 10.1016/j.micinf.2013.01.001
Abstrakt: Host defense peptides are ancient weapons of the innate immunity. The human cathelicidin LL-37 protects the epithelial barrier against infection and is constitutively secreted in the bloodstream by immune cells. Current knowledge claims that LL-37 is up regulated upon infection. LL-37 can protect against bacterial infections and possesses many immunomodulatory properties. Here, we show that the human host defense peptide LL-37 is down regulated during septic shock. Furthermore, we show that these effects are not related to vitamin D serum levels, a potent inducer of LL-37 gene expression, pointing out the complex regulation of cathelicidins during septic shock.
(Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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