| Autor: |
Takenami I; Advanced Laboratory of Public Health, Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Salvador, Bahia 40296 710, Brazil., Finkmoore B, Machado A Jr, Emodi K, Riley LW, Arruda S |
| Jazyk: |
angličtina |
| Zdroj: |
Pulmonary medicine [Pulm Med] 2012; Vol. 2012, pp. 757152. Date of Electronic Publication: 2012 Dec 17. |
| DOI: |
10.1155/2012/757152 |
| Abstrakt: |
Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P ≤ 0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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