Morbidity and outcome of severe respiratory syncytial virus infection.

Autor: El Kholy AA; Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt., Mostafa NA, El-Sherbini SA, Ali AA, Ismail RI, Magdy RI, Hamdy MS, Soliman MS
Jazyk: angličtina
Zdroj: Pediatrics international : official journal of the Japan Pediatric Society [Pediatr Int] 2013 Jun; Vol. 55 (3), pp. 283-8.
DOI: 10.1111/ped.12051
Abstrakt: Background: Respiratory syncytial virus (RSV) is the main cause of severe acute respiratory infection (SARI) in infants and young children. This study aimed to identify risk factors for intensive care unit (ICU) admission, prolonged length of stay (PLOS), and mortality in patients hospitalized with SARI caused by RSV.
Methods: This prospective cohort study included children hospitalized with SARI (according to the World Health Organization definition) and whose laboratory results proved RSV infection during the period from February 2010 to May 2011.
Results: Out of 240 enrolled patients, 24 patients (10%) were admitted to the ICU, 57 patients (24.3%) had a PLOS of >9 days and 12 patients (5%) died. The presence of cyanosis (P = 0.000; OR, 351.7) and lung consolidation (P = 0.006, OR, 9.3) were independent risk factors associated with ICU admission. The need for ICU admission (P = 0.000; OR, 6.1) and lung consolidation (P = 0.008, OR, 2.46) were independent risk factors associated with PLOS. The presence of an underlying congenital heart disease (P = 0.03, OR, 18.3), thrombocytopenia (P = 0.04, OR, 32.86) and mechanical ventilation (P = 0.000; OR, 449.4) were the only independent risk factors associated with mortality in our study.
Conclusions: Early recognition of risk factors for complicated RSV disease on admission prompts early interventions and early ICU admissions for these children.
(© 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.)
Databáze: MEDLINE
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