| Autor: |
Taucher M; Institute of Pathological Biochemistry, Medical Academy Carl Gustav Carus Dresden, GDR., Grässler J, Kühne H, Scheuch DW |
| Jazyk: |
angličtina |
| Zdroj: |
Zeitschrift fur medizinische Laboratoriumsdiagnostik [Z Med Lab Diagn] 1990; Vol. 31 (1), pp. 13-7. |
| Abstrakt: |
Effects of Hageman factor fragment (factor XIIf) administration on shock induction were studied in anesthetized male Wistar rats with hemorrhagic shock. Administration of factor XIIf in non-hemorrhaged rats resulted in an immediate decrease of mean arterial pressure (MAP) for 5 min and in significant increases of blood glucose, lactate and hematocrit (Hct) as well as in a strong tendency for plasma kallikreinogen (KKN) to decrease. At the beginning of bleeding (15 min after factor XIIf administration) MAP has been normalized again. During subsequent hemorrhage pretreated rats showed a sharper decrease in MAP which remained significantly lower up to 25% of estimated blood volume (EBV) and recovered more slowly to normal level after hemorrhage. Blood glucose, lactate and Hct were significantly higher in pretreated animals after hemorrhage of 30% EBV. KKN depicted significant lower values during hemorrhage and in the posthemorrhagic period. Mortality within the observation time increased from 20% (control group) to 60% (pretreated animals). The results demonstrate that prehemorrhagic kallikrein-kinin system (KKS) activation induced an increased severity of shock state with higher mortality. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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