A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome.

Autor:	Nestler JE; Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 980663, Richmond, VA 23298-0663, USA. jnestler@mcvh-vcu.edu, Reilly ER, Cheang KI, Bachmann LM, Downs RW Jr
Jazyk:	angličtina
Zdroj:	Transactions of the American Clinical and Climatological Association [Trans Am Clin Climatol Assoc] 2012; Vol. 123, pp. 209-19; discussion 219-20.
Abstrakt:	Introduction: We conducted a pilot project to test the hypothesis that decreasing insulin concentrations with diazoxide would affect parameters of vitamin D in obese women with and without polycystic ovary syndrome (PCOS). Materials and Methods: Eight obese women with PCOS and nine matched controls participated in the study. Diazoxide was administered orally 100 mg three times daily for 10 days, and parameters of vitamin D were measured at baseline and end-of-study. Results: At baseline, women with polycystic ovary syndrome had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than controls. After treatment with diazoxide, there were no significant changes in vitamin D parameters when PCOS and control women were evaluated separately. Diazoxide exhibited differential effects on 25(OH)D concentrations in PCOS as compared with normal women (P for interaction=0.045), and serum 25(OH)D levels converged after diazoxide treatment. Conclusions: Obese women with PCOS had significantly lower serum 25(OH)D levels at baseline than age- and body mass index-matched controls. Short-term administration with diazoxide seemed to have differential effects on 25(OH)D levels in PCOS as compared with control women. Further studies are necessary to confirm this finding.
Databáze:	MEDLINE
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