| Autor: |
Hartrampf S; Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. vandenbm@mskcc.org, Dudakov JA, Johnson LK, Smith OM, Tsai J, Singer NV, West ML, Hanash AM, Albert MH, Liu B, Toth M, van den Brink MR |
| Jazyk: |
angličtina |
| Zdroj: |
Blood [Blood] 2013 Mar 07; Vol. 121 (10), pp. 1906-10. Date of Electronic Publication: 2013 Jan 08. |
| DOI: |
10.1182/blood-2012-09-456590 |
| Abstrakt: |
Despite significant advances in prevention and management, graft versus host disease (GVHD) is still a leading complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although skin, gut, liver, thymus, and lung are GVHD targets, neurological complications (NC) have also been reported following allo-HSCT. We demonstrate that the central nervous system (CNS) can be a direct target of alloreactive T cells following allo-HSCT in mice. We found significant infiltration of the CNS with donor T lymphocytes and cell death of neurons and neuroglia in allo-HSCT recipients with GVHD. We also found that allo-HSCT recipients with GVHD had deficits in spatial learning/memory and demonstrated increased anxious behavior. These findings highlight CNS sensitivity to damage caused by alloreactive donor T cells and represent the first characterization of target cell subsets and NC during GVHD. Therefore, these clinically relevant studies offer a novel and rational explanation for the well-described neurological symptoms observed after allo-HSCT. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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