Oral tolerance and OVA-induced tolerogenic dendritic cells reduce the severity of collagen/ovalbumin-induced arthritis in mice.

Autor: Thomé R; Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas, Rua Monteiro Lobato, SP, Brazil. rodolfo.thome@gmail.com, Fernandes LG, Mineiro MF, Simioni PU, Joazeiro PP, Tamashiro WM
Jazyk: angličtina
Zdroj: Cellular immunology [Cell Immunol] 2012 Nov; Vol. 280 (1), pp. 113-23. Date of Electronic Publication: 2012 Dec 19.
DOI: 10.1016/j.cellimm.2012.11.017
Abstrakt: Dietary proteins play an important role in the regulation of systemic immune response, in a phenomenon known as oral tolerance (OT). To evaluate the effects of OT on a murine model of type II collagen (CII) plus ovalbumin (OVA)-induced arthritis (CIA), mice were fed with OVA either before or after CIA induction. OT significantly reduced the paw edema and synovial inflammation, as well as serum levels of anti-CII, the ex vivo proliferation and inflammatory cytokine production by spleen cells from CIA mice. The frequencies of Foxp3(+) and IL-10(+) cells were higher, whereas IFNγ(+) cells and IL-17(+) cells were lower, among gated CD4(+) spleen T cells from tolerized CIA mice than in those from non-tolerized CIA mice. Adoptive transfer of tolerogenic dendritic cells (DCs) before CIA induction mimics the effects observed in the OT. We demonstrate here that bystander suppression induced by OT can modify the course of CIA and tolerogenic DCs play a role this phenomenon.
(Copyright © 2012 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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