Cognitive impairment is correlated with reduced quality of life in patients with clinically isolated syndrome.

Autor:	Anhoque CF; Neuroscience Post-graduation Program, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Biccas-Neto L, Domingues SC, Teixeira AL, Domingues RB
Jazyk:	angličtina
Zdroj:	Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2013 Feb; Vol. 71 (2), pp. 74-7. Date of Electronic Publication: 2013 Jan 08.
DOI:	10.1590/s0004-282x2013005000004
Abstrakt:	Objective: To evaluate the quality of life (QoL) and potential QoL determinants in patients with clinically isolated syndrome (CIS). Methods: Eighteen CIS patients and eighteen controls were submitted to QoL evaluation with Functional Assessment of Multiple Sclerosis QoL instrument (FAMS). Cognition was evaluated with specific battery tests; Anxiety and depression with Beck Anxiety (BAI) and Depression (BDI) Inventories and Neurological disability with Guy's Neurological Disability Scale (GNDS). Results: There was a significant difference in QoL between CIS patients and controls. CIS patients had worse performance in Paced Auditory Serial Addition 2 seconds (p=0.009) and fluency tests (p=0.0038). There was a significant difference in BAI (p=0.003), but no significant difference in BDI between patients and controls. There were significant correlations between QoL measure and verbal fluency and Stroop's test. Conclusions: Cognition, but not anxiety, depression and disability, was associated with reduced quality of life.
Databáze:	MEDLINE
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