| Autor: |
Cable E; Department of Biochemistry, Emory University, Atlanta, GA 30322., Greene Y, Healey J, Evans CO, Bonkovsky H |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1990 Apr 16; Vol. 168 (1), pp. 176-81. |
| DOI: |
10.1016/0006-291x(90)91690-t |
| Abstrakt: |
Heme oxygenase, the rate controlling enzyme for heme catabolism, is inducible by a variety of treatments, some of which induce by a heme-dependent mechanism and others by a heme-independent mechanism. This work shows that, in cultured chick embryo liver cells, synergistic induction of heme oxygenase by iron, added with the phenobarbital-like drug, glutethimide was heme-dependent. Addition of an inhibitor of heme biosynthesis abolished the synergistic induction of heme oxygenase providing evidence for the heme-dependent mechanism of induction. Glutethimide and iron appeared to induce at the transcriptional level since both heme oxygenase mRNA and protein levels correlate with changes in heme oxygenase activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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