| Autor: |
Schenkelaars EJ; Erasmus University, Rotterdam, The Netherlands., Bonta IL, Ferrone S, Quagliata F |
| Jazyk: |
angličtina |
| Zdroj: |
Agents and actions [Agents Actions] 1990 Jan; Vol. 29 (1-2), pp. 111-3. |
| DOI: |
10.1007/BF01964735 |
| Abstrakt: |
Using rat peritoneal macrophages and blood monocytes we examined the relationship of developing adjuvant disease (AD) with the expression of class I and II antigens, release of interleukin-1 (IL-1) and production of prostaglandin E2 (PGE2). We observed that class I and II antigens initially decreased; class II remained low throughout, whereas class I returned to normal. PGE2 and IL-1 gradually increased. Treatment in vivo with the NSAID Na-diclofenac lowered PGE2 and IL-1 release and partly reversed the observed reduction of class I and II antigens. Also, exposure of the cells in vitro to lipopolysaccharide increased class I antigen expression. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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