Experimental comparison of the effects of locally administered zoledronic acid and alendronate on the rate of mandibular distraction osteogenesis in dogs.

Autor: Baiomy AA; Lecturer, Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Assiut), Al-Azhar University, Egypt., Nassan MA; Lecturer, Pathology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt. Electronic address: Moh_nassan@yahoo.com., Abdellatif EM; Professor of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Cairo), Al-Azhar University, Egypt., Abdel Fattah A; Professor and Head of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Assiut), Al-Azhar University, Egypt., El-Fekey AA; Lecturer, Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine (Cairo), Al-Azhar University, Egypt., Abdel Aal AB; Professor, Surgery Department, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Zagazig University, Egypt.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2014 Jul; Vol. 118 (1), pp. 35-42. Date of Electronic Publication: 2012 Dec 20.
DOI: 10.1016/j.oooo.2012.09.086
Abstrakt: Objective: The objective of this study was the evaluation of effects of locally administered zoledronic acid and alendronate on rate of osteogenesis in distracted mandible of dogs.
Study Design: Following mandibular corticotomy, bone segments were maintained in a neutral position by distractor for 7 days then distraction was initiated at a rate of 0.5 mm twice a day for 10 days to achieve a total distraction of 10 mm, followed by a consolidation period. Animals were divided into 3 equal groups according to the injected drug (saline solution [control], zoledronic acid, alendronate). The dogs were killed 2, 6, and 10 weeks following distraction and samples were collected for radiographic examination, assessment of bone mineral density, and histopathological evaluation.
Results: Radiographs and histopathological results pointed out that bone formation and maturation of experimental groups were faster than those of the control group.
Conclusions: Local administration of zoledronic acid and alendronate proved to be effective in shortening the consolidation period.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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