| Autor: |
Kreisberg JF; Genome Institute of Singapore, Singapore., Ong NT, Krishna A, Joseph TL, Wang J, Ong C, Ooi HA, Sung JC, Siew CC, Chang GC, Biot F, Cuccui J, Wren BW, Chan J, Sivalingam SP, Zhang LH, Verma C, Tan P |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Mar; Vol. 57 (3), pp. 1513-7. Date of Electronic Publication: 2012 Dec 21. |
| DOI: |
10.1128/AAC.02327-12 |
| Abstrakt: |
Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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