Fabrication, characterization and in vitro profile based interaction with eukaryotic and prokaryotic cells of alginate-chitosan-silica biocomposite.

Autor: Balaure PC; University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Organic Chemistry Department, Polizu Street No. 1-7, 011061 Bucharest, Romania., Andronescu E, Grumezescu AM, Ficai A, Huang KS, Yang CH, Chifiriuc CM, Lin YS
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2013 Jan 30; Vol. 441 (1-2), pp. 555-61. Date of Electronic Publication: 2012 Nov 20.
DOI: 10.1016/j.ijpharm.2012.10.045
Abstrakt: This work is focused on the fabrication of a new drug delivery system based on polyanionic matrix (e.g. sodium alginate), polycationic matrix (e.g. chitosan) and silica network. The FT-IR, SEM, DTA-TG, eukaryotic cell cycle and viability, and in vitro assay of the influence of the biocomposite on the efficacy of antibiotic drugs were investigated. The obtained results demonstrated the biocompatibility and the ability of the fabricated biocomposite to maintain or improve the efficacy of the following antibiotics: piperacillin-tazobactam, cefepime, piperacillin, imipenem, gentamicin, ceftazidime against Pseudomonas aeruginosa ATCC 27853 and cefazolin, cefaclor, cefuroxime, ceftriaxone, cefoxitin, trimethoprim/sulfamethoxazole against Escherichia coli ATCC 25922 reference strains.
(Copyright © 2012 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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