| Autor: |
Xu T; Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, United States., Ko HM, Savage NA, Dong G |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Chemical Society [J Am Chem Soc] 2012 Dec 12; Vol. 134 (49), pp. 20005-8. Date of Electronic Publication: 2012 Nov 28. |
| DOI: |
10.1021/ja309978c |
| Abstrakt: |
Here we report the first highly enantioselective Rh-catalyzed carboacylation of olefins via C-C bond activation of benzocyclobutenones. Good yields and excellent enantioselectivities (92-99% ee, 14 examples) were obtained for substrates with various steric and electronic properties. In addition, fully saturated poly-fused rings were prepared from the carboacylation products through a challenging catalytic reductive dearomatization approach. These investigations provide a distinct way to prepare chiral carbon frameworks that are nontrivial to access with conventional methods. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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