| Autor: |
Kim HB; Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea., Ahn KM, Kim KW, Shin YH, Yu J, Seo JH, Kim HY, Kwon JW, Kim BJ, Kwon JY, Choi SJ, Lee KJ, Park HJ, Won HS, Hong SJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of Korean medical science [J Korean Med Sci] 2012 Nov; Vol. 27 (11), pp. 1320-6. Date of Electronic Publication: 2012 Oct 30. |
| DOI: |
10.3346/jkms.2012.27.11.1320 |
| Abstrakt: |
Since the risk of developing allergic disease increases in individuals exposed to allergens previously, even during the neonatal period, the immunologic status of a fetus may be important in the subsequent development of allergy. We evaluated the fetal factors to predict atopic dermatitis (AD) at 12 months in 412 infants of a COhort for Childhood Origin of Asthma and Allergic Diseases (COCOA) in the general Korean population. Cord blood mononuclear cells (CBMCs) were stimulated with ovalbumin and phytohemagglutinin and cellular proliferative response and concentrations of interleukin-13 and interferon-γ, were measured. The risk of developing AD was greater in boys than girls (OR 1.97, 95% CI 1.26-3.09), infants delivered by cesarean section than vaginally (OR 1.93, 95% CI 1.14-3.26) and infants with than without parental history of AD (OR 2.34, 95% CI 1.29-4.24). The CBMC proliferative response to phytohemagglutinin stimulation was higher in infants with than without AD (P = 0.048), but no difference was observed in ovalbumin-stimulated cells (P = 0.771). Risk factors for the development of AD at 12 months include male gender, delivery by cesarean section and parental history of AD. Increased CBMC proliferative response to phytohemagglutinin stimulation may predict the development of AD at 12 months. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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