Amyloid imaging and cognitive decline in nondemented oldest-old: the 90+ Study.
| Autor: | Kawas CH; Department of Neurology, University of California, Irvine, Irvine, CA, USA. ckawas@uci.edu, Greenia DE, Bullain SS, Clark CM, Pontecorvo MJ, Joshi AD, Corrada MM |
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| Jazyk: | angličtina |
| Zdroj: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2013 Mar; Vol. 9 (2), pp. 199-203. Date of Electronic Publication: 2012 Nov 16. |
| DOI: | 10.1016/j.jalz.2012.06.005 |
| Abstrakt: | Background: The goal of this study was to examine cross-sectional and longitudinal associations between cognitive performance and beta amyloid (Aβ) load determined by florbetapir F18 positron emission tomography (PET) in nondemented oldest-old. Methods: Thirteen nondemented (normal or cognitively impaired nondemented) participants (median age, 94.2 years) from The 90+ Study underwent florbetapir-PET scanning within 3 months of baseline neuropsychological testing. Amyloid load was measured with a semi-automated quantitative analysis of average cortical-to-cerebellar standardized uptake value ratio (SUVr) and a visual interpretation (Aβ- or Aβ+). Neuropsychological testing was repeated every 6 months. Results: At baseline, SUVr correlated significantly with tests of global cognition and memory. During follow-up (median, 1.5 years), the Aβ+ group had steeper declines on most cognitive tests, particularly global cognitive measures. Conclusion: This preliminary study suggests that greater amyloid load is associated with poorer cognition and faster cognitive decline in nondemented oldest-old. Amyloid load may identify individuals at increased risk of developing Alzheimer's disease. (Copyright © 2013 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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