Boron-containing peptidomimetics--a novel class of selective anti-tubercular drugs.

Autor: Gorovoy AS; Department of Chemistry, University of Tromsø, N-9037 Tromsø, Norway., Gozhina OV, Svendsen JS, Domorad AA, Tetz GV, Tetz VV, Lejon T
Jazyk: angličtina
Zdroj: Chemical biology & drug design [Chem Biol Drug Des] 2013 Mar; Vol. 81 (3), pp. 408-13. Date of Electronic Publication: 2012 Dec 26.
DOI: 10.1111/cbdd.12091
Abstrakt: Medical treatment for tuberculosis is complicated nowadays by the appearance of new multiresistant strains, and therefore, new antibiotics are in great need. Here, we report the synthesis and in vitro testing of a new class of highly selective antimicrobial boron-containing peptidomimetics with compounds exhibiting activity against Mycobacterium tuberculosis at ≤5 μg/mL. The new approach developed makes it possible to synthesize variously substituted β-aminoboronic acids and their derivatives with a high level of diastereoselectivity.
(© 2012 John Wiley & Sons A/S.)
Databáze: MEDLINE
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