[Systemic endotoxinemia as a pathogenetic factor of pregnancy complication].

Autor:	Mavziutov AR, Bondarenko KR, Enikeev AN, Bondarenko VM
Jazyk:	ruština
Zdroj:	Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 2012 Sep-Oct (5), pp. 16-21.
Abstrakt:	Aim: Evaluation of the role of hemocirculation of a bacterial endotoxin in pregnancy complicated with gestosis. Materials and Methods: A complex clinical-laboratory examination of 74 pregnant women at the II-III trimester of gestational period including determination of serum cytokine levels (TNFalpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IFNgamma), C-reactive protein, LPS, LPS-binding protein and IgG against R-core LPS in blood plasma was performed. Results: In pregnant women with gestosis an increase in endotoxinemia level (p < 0.0001), twofold increase in IgG titers against R-core LPS (p < 0.01) and an increase in LBP concentration by 14% (p < 0.05) without an increase in concentration of C-reactive protein were shown. Cytokine profile in gestosis was characterized by a twofold statistically significant increase of IL-1beta (p < 0.0001), IL-8 (p < 0.0001) pro-inflammatory cytokine levels, a tendency of IL-6 (p = 0.063), TNFalpha (p = 0.13) increase and a decrease of Th1 cytokine concentrations: IL-2 - by 6.5 times (p < 0.0001), IFNgamma--by 2 times (p < 0.0001). Conclusion: The results allow to consider gestoses as a manifestation of increased endotoxin translocation into systemic blood flow during gestation, that determines the necessity to improve therapeutic measures in this pathology.
Databáze:	MEDLINE
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