MT2-MMP expression during early avian morphogenesis.

Autor: Patterson RA; Department of Biology, Creighton University, Omaha, Nebraska, USA., Cavanaugh AM, Cantemir V, Brauer PR, Reedy MV
Jazyk: angličtina
Zdroj: Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2013 Jan; Vol. 296 (1), pp. 64-70. Date of Electronic Publication: 2012 Nov 15.
DOI: 10.1002/ar.22618
Abstrakt: Membrane-type 2 matrix metalloproteinase (MT2-MMP; also called MMP15) is a membrane-bound protease that degrades extracellular matrix and activates proMMPs such as proMMP-2. MMP-2 expression in avian embryos is well documented, but it is not clear how proMMP-2 is activated during avian embryogenesis. Herein, we report that MT2-MMP mRNA is expressed in several tissues including the neural folds and epidermal ectoderm, intermediate mesoderm, pharyngeal arches, limb buds, and dermis. Several, but not all, of these tissues are known to express MMP-2. These observations suggest MT2-MMP may play a role during embryonic development not only through its own proteolytic activity but also by activating proMMP-2.
(Copyright © 2012 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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