Non-neutral evolution in non-LEE-encoded type III effectors of attaching and effacing Escherichia coli.

Autor: Eswarappa SM; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. eswaras@ccf.org, Janice J, Balasundaram SV, Chakravortty D
Jazyk: angličtina
Zdroj: Microbes and infection [Microbes Infect] 2013 Feb; Vol. 15 (2), pp. 147-51. Date of Electronic Publication: 2012 Nov 07.
DOI: 10.1016/j.micinf.2012.10.015
Abstrakt: Attaching and effacing Escherichia coli (AEEC) employ type III secretion system (T3SS) to secrete effector proteins into host cells and regulate their function. Here we have investigated T3SS genes of AEEC for non-neutral evolution. Our analysis revealed non-neutral evolution in three genes (nleE1, nleB2 and nleD) which encode effector proteins. These genes are located outside the locus of enterocyte effacement (LEE). In general, non-LEE effector genes show greater deviation from neutral evolution than LEE effector genes. These results suggest that effector genes located outside LEE are under greater selection pressure than those present in LEE.
(Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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