| Autor: |
Khapchaev AIu, Samsonov MV, Kazakova OA, Vilitkevich EL, Sidorova MV, Az'muko AA, Molokoedov AS, Bespalova ZhD, Shirinskiĭ VP |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 2012 Sep-Oct; Vol. 57 (5), pp. 764-70. |
| Abstrakt: |
Novel peptides originating from the peptide inhibitor of myosin light chain kinase, L-PIK (Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys), have been studied for ability to attenuate the thrombin-induced hyperpermeability of endothelial cell monolayer in culture. Peptides [NalphaMeArg1]-Lys-Lys-Tyr-Lys-Tyr-Arg-(D)Arg8-Lys and H-Arg(NO2)Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2 (designated PIK2 and PIK4, respectively) appeared to be the most effective inhibitors of endothelial cell monolayer hyperpermebility, and surpassed other known peptide inhibitors of myosin light chain kinase derived from original L-PIK. Our results validate PIK2 and PIK4 as the leading molecules for the development of novel drugs intended to counteract pathological hyperpermeability of vascular endothelium. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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