Differential brain response to alcohol cue distractors across stages of alcohol dependence.

Autor: Fryer SL; Department of Psychiatry, University of California, San Francisco, CA, USA., Jorgensen KW, Yetter EJ, Daurignac EC, Watson TD, Shanbhag H, Krystal JH, Mathalon DH
Jazyk: angličtina
Zdroj: Biological psychology [Biol Psychol] 2013 Feb; Vol. 92 (2), pp. 282-91. Date of Electronic Publication: 2012 Nov 03.
DOI: 10.1016/j.biopsycho.2012.10.004
Abstrakt: Altered attention to alcohol-related cues is implicated in the craving and relapse cycle characteristic of alcohol dependence (ALC). Prior cue reactivity studies typically invoke explicit attention to alcohol cues, so the neural response underlying incidental cue exposure remains unclear. Here, we embed infrequent, task-irrelevant alcohol and non-alcohol cues in an attention-demanding task, enabling evaluation of brain responses to distracting alcohol cues. Alcohol dependent individuals, across illness phase (n=44), and controls (n=20) performed a cue-reactivity fMRI target detection task. Significant Group-by-Distractor effects were observed in dorsal anterior cingulate cortex (ACC), inferior parietal lobule, and amygdala. Controls and long-term abstainers increased recruitment of attention and cognitive control regions, while recent and long-term abstainers decreased limbic recruitment to alcohol distractors. Across phases of ALC, self-reported craving positively correlated with cue-related activations in ventral ACC, medial prefrontal cortex, and cerebellum. Results indicate that brain responses elicited by incidental alcohol cues differentiate phases of ALC.
(Copyright © 2012 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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