Molecular detection of HPV and Chlamydia trachomatis infections in Brazilian women with abnormal cervical cytology.

Autor: de Abreu AL; Departments of Clinical Analysis and Biomedicine, Medicine, and Basic Science of Health, Universidade Estadual de Maringá, Maringá, Paraná, Brazil. andreluelsdorf@gmail.com, Nogara PR, Souza RP, da Silva MC, Uchimura NS, Zanko RL, Ferreira EC, Tognim MC, Teixeira JJ, Gimenes F, Consolaro ME
Jazyk: angličtina
Zdroj: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2012 Dec; Vol. 87 (6), pp. 1149-51. Date of Electronic Publication: 2012 Nov 05.
DOI: 10.4269/ajtmh.2012.12-0287
Abstrakt: The question of whether Chlamydia trachomatis (Ct) is a cofactor for human Papillomavirus (HPV) in cervical carcinogenesis is still controversial. We conducted a molecular detection study of both infections in 622 Brazilian women, including 252 women with different grades of abnormal cervical cytology and cervical cancer (CC; cases) and 370 women with normal cytology (controls). Although Ct infection did not seem related to CC carcinogenicity, women with abnormal cytology had a significant high rate of Ct infection. Therefore, it is important to adopt protocols for diagnosis and treatment of this bacterium in conjunction with screening for CC in this population.
Databáze: MEDLINE