| Autor: |
Nawwar MA; Department of Phytochemistry and Plant Systematic; National Research Center; Dokki, Cairo, Egypt., Swilam NF; Institute for Pharmacy; Pharmaceutical Biology; Ernst-Moritz-Arndt-University Greifswald; Greifswald, Germany., Hashim AN; Department of Phytochemistry and Plant Systematic; National Research Center; Dokki, Cairo, Egypt., Al-Abd AM; Department of Pharmacology; National Research Center; Dokki, Cairo, Egypt., Abdel-Naim AB; Department of Pharmacology and Toxicology; Ain Shams University; Cairo, Egypt., Lindequist U; Institute for Pharmacy; Pharmaceutical Biology; Ernst-Moritz-Arndt-University Greifswald; Greifswald, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Plant signaling & behavior [Plant Signal Behav] 2013 Jan; Vol. 8 (1), pp. e22642. Date of Electronic Publication: 2012 Nov 03. |
| DOI: |
10.4161/psb.22642 |
| Abstrakt: |
Tamgermanitin, a unique N-trans-Isoferuloyltyramine, together with the hitherto unknown polyphenolics, 2,4-di-O-galloyl-(α/β)-glucopyranose and kaempferide 3,7-disulphate have been isolated from the leaf aqueous ethanol extract of the false tamarisk, Myricaria germanica DESV. In addition, 18 known phenolics were also separated and characterized. All structures were elucidated on the basis of detailed analysis of 1D- (1)H and (13)C NMR, COSY, HSQC, HMBC and HRFTESIMS spectral data. The extract, its chromatographic column fractions and the isolated isoferuloyltyramine, tamgermanetin demonstrated potential cytotoxic effect against three different tumor cell lines, namely liver (Huh-7), breast (MCF-7) and prostate (PC-3). The IC 50''s were found to be substantially low with low-resistance possibility. DNA flow-cytometic analysis indicated that column fractions and tamgermanetin enhanced pre-G apoptotic fraction. Both materials showed inhibiting activity against PARP enzyme activity. In conclusion, we report the isolation and identification of a novel compound, tamgermanitin, from the aqueous ethanol extract of Myricaria germanica leaves. Further, different fractions of the extract and tamgermanitin exhibit potent cytotoxic activities which warrant further investigations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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