| Autor: |
Postnikova OA; Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru, Nepomnyashchikh GI, Yudanov AV, Nepomnyashchikh DL, Kapustina VI, Isayenko VI |
| Jazyk: |
English; Russian |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Oct; Vol. 153 (6), pp. 898-901. |
| DOI: |
10.1007/s10517-012-1854-x |
| Abstrakt: |
Structural analysis of hepatocytes in liver biopsy specimens from patients with hepatitis C and C+B with intracellular cholestasis was carried out. Large foci of bile components in hepatocytes led to cell damage, eventuating in cell destruction and death. The cholestatic variant of mixed infection was characterized by destructive necrotic changes in hepatocytes and progressive fibrosis of the liver. Destruction of the hepatocyte cytoplasmic organelles was associated with high activity of the infectious process and pronounced cytolytic syndrome. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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