| Autor: |
Kalitin NN; Research Institute of Carcinogenesis, Moscow, Russia., Kostyukova MN, Kakpakova ES, Tupitsyn NN, Karamysheva AF |
| Jazyk: |
English; Russian |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Oct; Vol. 153 (6), pp. 882-5. |
| DOI: |
10.1007/s10517-012-1850-1 |
| Abstrakt: |
We studied the expression of genes encoding vascular endothelial growth factors VEGF-A, VEGF-C, VEGF-D and their receptors in cell cultures of human multiple myeloma IM9, RPMI 1640, RPMI 8226. The studied cells did not differ by the expression of growth factors. Expression of VEGFR1 receptor was detected only in IM9 cells and VEGFR2 and VEGFR3 receptors were not expressed in multiple myeloma cells. A dependence between the aberrant CD45/CD56 phenotype of human multiple myeloma cells and VEGFR1 expression in them was revealed. The only VEGFR1-positive IM9 cell culture was most resistant to Velcade (bortezomib). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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