| Autor: |
Ebeid Mel-S; Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), Minufiya University, Sadat City, Egypt ; Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), Minufiya University, Sadat City, Egypt P.O 22857-79., El-Bakry KA |
| Jazyk: |
angličtina |
| Zdroj: |
Indian journal of clinical biochemistry : IJCB [Indian J Clin Biochem] 2009 Jul; Vol. 24 (3), pp. 234-40. Date of Electronic Publication: 2009 Sep 16. |
| DOI: |
10.1007/s12291-009-0044-8 |
| Abstrakt: |
The present study aimed to estimate the cellular immune response to infection by different HCV genotypes in some Egyptian patients with chronic liver disease. HCV-RNA and HCV genotypes were conducted using type-specific primers to amplify the core region of HCV genome. The levels of IFN-gamma and TNF-alpha, PIIINP, SOD enzyme were also determined. The results showed that genotype 4 was the prevalent one (88.57%).Genotype 3 was found mixed with genotype 2 and 4 (11.42% and 34.28% respectively). Genotype 1 was absent from patients under study. No significant differences were observed in the level of IFN-gamma interferon, SOD enzyme and ALT enzyme between those genotypes. On the other hand the level of TNF-alpha was greatly increased in patients infected with mixed HCV genotypes 3, 4 compared with patients with genotype 4 and those infected with mixed genotypes 2, 3. Otherwise PIIINP was decreased significantly of the same group compared with other groups. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink