| Autor: |
Kotovshchikova EF, Buevich EI, Pen'kova EV, Kulikov VP, Chudimov VF, Siul'zhina EN, Bogdanova IV, Bochkarev AP |
| Jazyk: |
ruština |
| Zdroj: |
Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2012 Aug (8), pp. 33-6. |
| Abstrakt: |
The examination was applied to sampling of 238 patients of younger age with neurologic symptomatology under connective tissue dysplasia and 46 healthy persons. The venous cerebral angiodystonia was diagnosed in 153 (64.3%) patients with connective tissue dysplasia. The results are confirmed by duplex analysis of cerebral and vertebral vessels. The mutations of genes of blood coagulation system (FV Leiden, FII, MTHFR, FVII and PAI-1) are established. They include combined (61.4%) and independent (23.5%) groups of mutation. Alongside with it, in 23 (19.6%) patients disorders of hemostasis are presented as von Willebrand factor deficiency and in 105 (89.7%) patients as decrease of aggregation function of thrombocytes and disorders of final coagulation stage of blood coagulation. The results of study indicate the equally frequent risk of thrombotic and hemorrhagic complications in patients with connective tissue dysplasia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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