| Autor: |
de Aquino PF; Departamento de Química, Universidade Federal do Amazonas, Manaus, AM, Brasil., Carvalho PC, da Gama Fischer JS, de Souza AQ, Viana JS, Chalub SR, de Souza AD, Carvalho MG |
| Jazyk: |
angličtina |
| Zdroj: |
Genetics and molecular research : GMR [Genet Mol Res] 2012 Dec 17; Vol. 11 (4), pp. 4442-6. Date of Electronic Publication: 2012 Dec 17. |
| DOI: |
10.4238/2012.October.15.3 |
| Abstrakt: |
Gastric cancer is one of most frequent causes of death in Brazil. The city of Manaus has one of the highest incidences of this disease in Brazil. The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is classified as a group 1 carcinogen by the International Agency for Research on Cancer. We obtained biopsies from 6 control subjects and 10 patients with gastric carcinomas living in Manaus. In the patients, the samples were taken from tumors and from adjacent non-cancerous mucosa. These samples were screened for EBV DNA by PCR to amplify the 288-bp fragments from the Bam M region. The EBV DNA was detected in 8 of the 10 tumor cases and in none of the 6 control subjects. In the positively identified samples, EBV DNA was detected in five corresponding resection margins. Previous research indicated only a weak association between EBV and gastric cancer. We suggest that EBV should be considered as a risk factor for gastric adenocarcinomas in Manaus. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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