Adsorption of multimeric T cell antigens on carbon nanotubes: effect on protein structure and antigen-specific T cell stimulation.
| Autor: | Fadel TR; Department of Chemical and Biomedical Engineering, Yale University, P.O. Box 208284, New Haven, Connecticut, USA., Li N, Shah S, Look M, Pfefferle LD, Haller GL, Justesen S, Wilson CJ, Fahmy TM |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Small (Weinheim an der Bergstrasse, Germany) [Small] 2013 Mar 11; Vol. 9 (5), pp. 666-72. Date of Electronic Publication: 2012 Oct 23. |
| DOI: | 10.1002/smll.201201684 |
| Abstrakt: | Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates ((b) CNTs). To overcome the denaturing effects of direct adsorption on (b) CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin. (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|
Plný text