| Autor: |
Bosînceanu A; Discipline of Pharmaceutical Technology, School of Pharmacy, University of Medicine and Pharmacy, 'Grigore T. Popa', Iasi., Popa G, Tântaru G, Popovici I |
| Jazyk: |
angličtina |
| Zdroj: |
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi [Rev Med Chir Soc Med Nat Iasi] 2012 Jan-Mar; Vol. 116 (1), pp. 330-5. |
| Abstrakt: |
Amiodarone is an antiarrhythmic agent used for various types of tachyarrhythmia, both ventricular and supraventricular (atrial) arrhythmia. A spectrophotometric method for the assay of amiodarone was established. Based on the reduction of potassium ferricyanide in hydrochloric acid medium to potassium ferrocyanide forming a blue colored complex ferric ferrocyanide with Fe (III) ions. The compound was most stable in a mixture of ethylic alcohol and water (2:1, v/v) and it had an absorption maximum at 725 nm. The data were according to the Lambert-Beer Law in the concentration range of 0.5-5.0 microg/sample: correlation and coefficient R = 0.99977, R2 = 0.999541, slope of the line 0.12775, intercept 0.042077. The detection limit (DL) was 0.1032 microg/sample and the quantification limit (QL) 0.344 microg/ sample. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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