| Autor: |
Scavone JM; Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts., Greenblatt DJ, Blyden GT, Luna BG, Harmatz JS |
| Jazyk: |
angličtina |
| Zdroj: |
Therapeutic drug monitoring [Ther Drug Monit] 1990 Jan; Vol. 12 (1), pp. 35-9. |
| DOI: |
10.1097/00007691-199001000-00007 |
| Abstrakt: |
The pharmacokinetics of a single 650-mg intravenous dose of acetaminophen were determined in 82 volunteers using multiple (13 or more) plasma acetaminophen concentrations measured by high pressure liquid chromatography during 24 h after dosage. Kinetic values from the complete study were compared with kinetic estimates based on only two data points: (a) the 2- and 6-h points only; and (b) the 3 and 6-h points only. For elimination half-life, values from the complete study (mean 2.42 h) were highly correlated (r = 0.87 and 0.84) with methods a and b (means 2.41 and 2.43 h), with regression slopes of 1.00 and 0.99, respectively. For clearance, the complete study values (mean 312 ml/min) were highly correlated (r = 0.97 and 0.97) with method a and b values, but both two-point methods significantly overestimated clearance (means 350 and 355 ml/min) by an average of 13 and 14%, respectively. Results for volume of distribution were similar to those for clearance. Although acetaminophen elimination half-life can be estimated with reasonable precision using a two-point blood-sampling procedure, clearance and volume of distribution values using the two-point method overestimate the actual values. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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