Levodopa versus non-levodopa brain language fMRI in Parkinson's disease.
| Autor: | Arantes PR; Instituto do Cérebro, Hospital Israelita Albert Einstein., Gobato HH, Davoglio BB, Barreiros MÂ, Felício AC, Barsottini OG, Andrade LA, Amaro Junior E |
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| Jazyk: | English; Portuguese |
| Zdroj: | Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2012 Apr-Jun; Vol. 10 (2), pp. 171-9. |
| DOI: | 10.1590/s1679-45082012000200010 |
| Abstrakt: | Objective: To identify the effect of levodopa in language areas in Parkinson's disease patients. Methods: We evaluated 50 patients with mild to moderate Parkinson's disease, age and gender paired to 47 healthy volunteers. We selected two homogeneous groups of 18 patients taking levodopa and 7 no levodopa patients. The functional magnetic resonance imaging verbal fluency task, with low and high cognitive demands, was performed at a 3T magnetic resonance imaging equipment. Data was analyzed with XBAM software for group maps and ANOVA comparison. Results: Patients without levodopa had more activation than the ones with levodopa in the medial frontal and in the left frontal and parieto-occipital areas. The striatal activation in patients taking levodopa had similar result of the activation detected in the healthy volunteer group. Parieto-occipital areas were less activated in the levodopa group than in the no levodopa one. Conclusion: Parkinson's disease patients without levodopa replacement, during a verbal fluency effort, had more diffuse and intense cerebral activation in left hemisphere, mainly in the frontal and parieto-occipital areas. The striatal activation in verbal fluency of patients with levodopa intake was more similar to the activation found in healthy volunteers. These initial evidences suggested a role of levodopa inhibiting activation in parieto-occipital compensating areas. |
| Databáze: | MEDLINE |
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