| Autor: |
Azimian M; Division of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, USA., Gultekin SH, Hata JL, Atkinson JB, Ely KA, Fuchs HA, Mobley BC |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases [J Clin Rheumatol] 2012 Oct; Vol. 18 (7), pp. 363-6. |
| DOI: |
10.1097/RHU.0b013e31826852db |
| Abstrakt: |
Chloroquine and hydroxychloroquine are used to chronically treat certain rheumatologic diseases and are generally considered safe. We describe 2 patients with skeletal myopathy and fatal cardiomyopathy-uncommon and underrecognized adverse effects of these agents. Both patients developed arrhythmias and heart failure, and 1 patient had documented diaphragmatic involvement. Muscle specimens showed typical vacuolar myopathy (indicative of impaired autophagy) with myeloid bodies in both patients and curvilinear bodies in 1 patient. Antimalarial-induced cardiomyopathy should be considered in patients receiving these medications with otherwise unexplained muscle weakness or cardiac symptoms. Whether autophagy enhancers can be used to manage such myopathies merits investigation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
