Antiherpetic activity of an Agaricus brasiliensis polysaccharide, its sulfated derivative and fractions.

Autor: Yamamoto KA; Departamento de Microbiologia, CCB, Universidade Estadual de Londrina, Londrina, Paraná, Brazil., Galhardi LC, Rincão VP, Soares Sde A, Vieira IG, Ricardo NM, Nozawa C, Linhares RE
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2013 Jan; Vol. 52, pp. 9-13. Date of Electronic Publication: 2012 Oct 05.
DOI: 10.1016/j.ijbiomac.2012.09.029
Abstrakt: Agaricus brasiliensis is an edible mushroom, traditionally used for the treatment of several diseases. In this paper, a polysaccharide (PLS) from A. brasiliensis, its carboxymethylated (CPLS) and sulfated (SPLS) derivatives, as well as, fractions (F1-F3) obtained from the PLS were investigated for their effect in the replication of herpes simplex virus and bovine herpes virus in HEp-2 cell cultures. The PLS, SPLS and F3 inhibited both virus strains similarly, in a dose-dependent curve. F1, F2 and CPLS did not show significant effect even at higher concentrations. All the compounds showed neither virucidal or viral adsorption inhibition activities nor effect when cells were treated prior to infection. Our study demonstrated that the extracts of A. brasiliensis, can be promising for future antiviral drug design and its biotechnological production is economically feasible.
(Copyright © 2012 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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