Structure formation and hydrogen bonding in all-aliphatic segmented copolymers with uniform hard segments.

Autor: Odarchenko YI; Institut de Sciences des Matériaux de Mulhouse-IS2M, CNRS LRC 7228, Mulhouse, France., Sijbrandi NJ, Rosenthal M, Kimenai AJ, Mes EP, Broos R, Bar G, Dijkstra PJ, Feijen J, Ivanov DA
Jazyk: angličtina
Zdroj: Acta biomaterialia [Acta Biomater] 2013 Apr; Vol. 9 (4), pp. 6143-9. Date of Electronic Publication: 2012 Oct 04.
DOI: 10.1016/j.actbio.2012.09.038
Abstrakt: Fully aliphatic segmented poly(ether ester amide) copolymers with uniform hard segments prepared by melt polycondensation of α,ω-hydroxyl end-functionalized polytetrahydrofuran and short glycine or β-alanine bisester-bisoxalamide units hold promise for biomedical applications. For polymers with the hard block contents varying from 10% to 27%, differential scanning calorimetry and atomic force microscopy reveal a highly phase-separated morphology, with ribbon-like nanocrystals dispersed in the soft segment matrix. To relate the polymer properties to the structure of the hard segment, the monomers were prepared and studied by optical and X-ray diffraction measurements. It was shown that the glycine and β-alanine carbonyl ester groups are tilted away from the oxalamide plane, which can affect the degradation rate via hydrolysis of the ester bond.
(Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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