Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium.

Autor: Prajapat MK; Chemical Engineering, Indian Institute of Technology Gandhinagar, VGEC Campus, Chandkheda, Ahmedabad, Gujarat 382424, India., Saini S
Jazyk: angličtina
Zdroj: Computers in biology and medicine [Comput Biol Med] 2012 Nov; Vol. 42 (11), pp. 1133-40. Date of Electronic Publication: 2012 Oct 04.
DOI: 10.1016/j.compbiomed.2012.09.005
Abstrakt: Salmonella enterica is responsible for a large number of diseases in a wide-range of hosts. Two of the global regulators involved in controlling gene expression during the infection cycle of the bacterium are Fur and HNS. In this paper, we demonstrate computationally that Fur and HNS have disproportionately high density of binding sites in the Pathogenicity Islands on the Salmonella chromosome. Moreover, the frequency of binding sites for the two proteins is correlated throughout the genome of the organism. These results indicate a complex interplay between Fur and HNS in regulating cellular global behavior.
(Copyright © 2012 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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