IGF2/ApaI polymorphism associated with birth weight in children of the region of Petrolina-PE, Brazil.

Autor: de Mascena Diniz Maia PF; Federal University of Vale do São Francisco, Petrolina-PE, Brazil., da Silva TM, Angelo HD, e Silva LW, Gondim Martins DB, de Mascena Diniz Maia M, de Lima Filho JL
Jazyk: angličtina
Zdroj: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2013 Feb; Vol. 26 (3), pp. 316-7. Date of Electronic Publication: 2012 Oct 18.
DOI: 10.3109/14767058.2012.733769
Abstrakt: Insulin-like growth factor 2 (IGF2) gene has an important role in fetal growth. It was investigated association of the IGF2/ApaI polymorphism with low birth weight and normal birth weight (as control) in children attended in Hospital Dom Malan Petrolina, PE-Brazil. The genotype frequencies did not differ statistically between low birth weight (AA = 16.22%, AG = 43.24%, GG = 40.54%) and control (AA = 20% AG = 35%, GG= 45% groups) and the allele frequencies were not significantly different (p > 0.05).The observed genotype frequencies in both groups did not deviate significantly from Hardy-Weinberg equilibrium. Then, no significant correlation was found for this polymorphism in the population studied.
Databáze: MEDLINE