Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms.

Autor: Yildiz SH; Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey handanstarr@gmail.com., Erdogan MO; Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey., Artan S; Department of Medical Genetics, Eskisehir Osmangazi University, Eskisehir, Turkey., Solak M; Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey., Yaman M; Department of Neurology, Afyon Kocatepe University, Afyonkarahisar, Turkey., Ozbabalik BD; Department of Neurology, Eskisehir Osmangazi University, Eskisehir, Turkey., Terzi ES; Department of Medical Genetics, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Jazyk: angličtina
Zdroj: American journal of Alzheimer's disease and other dementias [Am J Alzheimers Dis Other Demen] 2015 Dec; Vol. 30 (8), pp. 756-61. Date of Electronic Publication: 2012 Oct 04.
DOI: 10.1177/1533317512461557
Abstrakt: Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer's disease (AD). Moreover, interleukin-1α (IL-1α) is found to be associated with the pathogenesis of AD. In this research, ∊2, ∊3, and ∊4 polymorphisms of ApoE gene and C889T polymorphism of IL-1α gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. ∊3/∊3 and ∊3/∊4 genotype frequencies were significantly higher in control and case groups, respectively. While ∊3 allele frequencies were significantly higher in the control group, ∊2 and ∊4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1α. In conclusion, we demonstrated that there was a strong association between ApoE ∊4 allele and AD, while there was no relation with IL-1α C889T polymorphisms for this study.
(© The Author(s) 2012.)
Databáze: MEDLINE
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