[Comparative study of the influence of succinate-containing preparations on mitochondrial respiration in rat brain cells].
| Autor: | Iasnetsov VV, Prosvirova EP, Tsublova EG |
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| Jazyk: | ruština |
| Zdroj: | Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2012; Vol. 75 (7), pp. 8-10. |
| Abstrakt: | It has been established by polarographic measurements that preparations containing succinate, such as cytoflavin (0.85 mM succinate), mexidol, and amtizol succinate (at a concentration of 0.85 mM) but not reamberin (0.045 mM succinate), nearly equally (by 35-45%) increase oxygen consumption in rat brain mitochondria. On the other hand, malonate - inhibitor of the respiratory complex II (succinate dehydrogenase) of mitochondrial chain suppressed the stimulating effect of these drugs. |
| Databáze: | MEDLINE |
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