| Autor: |
Yang AH; Department of Pathology, Taipei Veterans General Hospital, Rm. 6047, Medical Technology Building, Taipei, 11217, Taiwan. ahyang@vghtpe.gov.tw, Chau YP, Lee CH, Chen JY, Chen JY, Ke CC, Liu RS |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical & experimental metastasis [Clin Exp Metastasis] 2013 Mar; Vol. 30 (3), pp. 299-307. Date of Electronic Publication: 2012 Sep 27. |
| DOI: |
10.1007/s10585-012-9537-6 |
| Abstrakt: |
We previously showed that the preservation of neural adhesion molecule (NCAM) in differentiated thyroid carcinoma is an important indicator for a higher risk of distant metastasis. In the present study, we further demonstrated that forced NCAM-140 isoform expression in human thyroid cancer cells could lead to aggressive growth by enhancing migration and anchorage-independent growth, and exhibiting partial features of epithelial mesenchymal transition. More extensive distant metastasis was also noted in an animal xenograft model when NCAM-expressing thyroid cancer cells were introduced into mice intravascularly. Bioinformatic analysis of NCAM-associated expression profiles predicted a highly interactive protein network, which further implies potential molecular mechanisms underlying the metastatic processes of thyroid cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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