Alfaxalone and medetomidine intravenous infusion to maintain anaesthesia in colts undergoing field castration.

Autor: Goodwin WA; School of Veterinary Science, University of Queensland, Queensland, Australia. w.goodwin@uq.edu.au, Keates HL, Pearson M, Pasloske K
Jazyk: angličtina
Zdroj: Equine veterinary journal [Equine Vet J] 2013 May; Vol. 45 (3), pp. 315-9. Date of Electronic Publication: 2012 Sep 25.
DOI: 10.1111/j.2042-3306.2012.00645.x
Abstrakt: Reasons for Performing the Study: The use of alfaxalone and medetomidine administered as an i.v. infusion to maintain anaesthesia has not previously been reported in the horse.
Objectives: To investigate the use of alfaxalone in hydroxpropyl-beta-cyclodextrin (Alfaxan) and medetomidine infusion as a field anaesthetic for short-term surgical procedures in the horse.
Hypothesis: Alfaxalone-medetomidine anaesthesia is suitable for short-term field anaesthesia in horses.
Methods: Eleven healthy colts underwent 45 min of anaesthesia with an i.v. infusion of alfaxalone (2 mg/kg bwt/h) and medetomidine (5 μg/kg bwt/h) for routine field castration. Horses were premedicated with i.v. acepromazine (0.03 mg/kg bwt), medetomidine (7 μg/kg bwt) and guaiphenesin (35 mg/kg bwt) before i.v. induction with alfaxalone (1 mg/kg bwt). Colts were intubated with an endotracheal tube and 100% oxygen insufflated at 10 l/min. The physiological variables monitored included pulse rate, respiratory rate, direct arterial blood pressure, arterial blood gases and the quality of the inductions and recoveries were scored.
Results: Overall, the anaesthetic period and surgical conditions were acceptable and the quality of the anaesthetic inductions and recoveries was good to excellent. All colts stood on their first attempt (mean ± s.d.) 37 ± 13.5 min after the infusion was stopped. During anaesthesia, cardiopulmonary data, presented as range of mean values at each time point were: heart rate: 45-47 beats/min; mean blood pressure: 104-112 mmHg; respiratory rate: 8 breaths/min; PaO2 : 117-172 mmHg; PaCO2 : 50-56 mmHg and pH 7.34-7.37.
Conclusions and Potential Relevance: The co-administration of alfaxalone and medetomidine as an i.v. infusion after anaesthetic induction with alfaxalone was suitable for short-term field anaesthesia in the horse.
(© 2012 EVJ Ltd.)
Databáze: MEDLINE
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