[Two multidrug-resistant Salmonella infantis isolates behave like hypo-invasive strains but have high intracellular proliferation].

Autor: Di Conza JA; Facultad de Farmacia y Bioquímica - Universidad de BuenosAires, Junin 956 (1113) Ciudad Autónoma de Buenos Aires, Argentina. jdiconza@fbcb.unl.edu.ar, Mollerach ME, Gutkind GO, Ayala JA
Jazyk: Spanish; Castilian
Zdroj: Revista Argentina de microbiologia [Rev Argent Microbiol] 2012 Apr-Jun; Vol. 44 (2), pp. 69-74.
Abstrakt: In this work, plasmid-encoded virulence factors in two Salmonella Infantis isolates carrying multiresistance plasmids were investigated. In addition, their invasion and proliferative ability in non-phagocytic cells was studied. None of them showed the typical determinants of virulence plasmids (spy operon). The invasion assays of S. Infantis isolates on eukaryotic cells showed a decreased ability to invade but they remained and proliferated in the cytoplasm regardless of having used a permissive (HeLa) or non-permissive (NRK) cell line. Finally, there was no microscopic evidence suggesting a bactericidal effect of these eukaryotic cell lines on the isolates tested.
Databáze: MEDLINE