Effects of a Pseudomonas aeruginosa eradication policy in a cystic fibrosis clinic.

Autor:	Davidson AG; Department of Pediatrics, Faculty of Medicine, University of British Columbia, and Cystic Fibrosis Clinic, BC Children's Hospital, Vancouver, British Columbia, Canada. GDavidson@cw.bc.ca, Chilvers MA, Lillquist YP
Jazyk:	angličtina
Zdroj:	Current opinion in pulmonary medicine [Curr Opin Pulm Med] 2012 Nov; Vol. 18 (6), pp. 615-21.
DOI:	10.1097/MCP.0b013e328358f5a2
Abstrakt:	Purpose of Review: This review is based upon the recent literature regarding eradication of newly acquired infection with Pseudomonas aeruginosa (Psa) in patients with cystic fibrosis (CF) and the economic and other effects of such an early eradication policy in a CF clinic. Recent Findings: Various Psa eradication protocols which utilize intravenous or aerosol anti-pseudomonal antibiotics, with or without oral antibiotics, have been reported. The recent ELITE trial reported successful eradication of 90% of Psa in selected Psa antibody negative patients after 28 days of tobramycin for inhalation. Another recent report of a protocol based on intravenous antibiotic use reported elimination of 'first growth' Psa in over 96% of all patients, accompanied by decreased chronic Psa infection, decreased anti-Psa treatment costs and decreased hospitalization costs. Summary: The effects of early eradication protocols for Psa have included decreased prevalence of chronic Psa infection, improved patient health and pulmonary function, and decreased hospital and antibiotic costs.
Databáze:	MEDLINE
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