| Autor: |
Kaiser R; Institut für Virologie und Immunbiologie der Universität Würzburg, BRD., Dörries R, ter Meulen J, Kidenya JJ, Pöllath M, Fleischer K, ter Meulen V |
| Jazyk: |
angličtina |
| Zdroj: |
European neurology [Eur Neurol] 1990; Vol. 30 (1), pp. 27-31. |
| DOI: |
10.1159/000116621 |
| Abstrakt: |
The intrathecal synthesis of antibodies to human immunodeficiency virus (HIV) was determined by 3 different immunoassays in 15 African patients with pre-acquired immunodeficiency syndrome (AIDS) and AIDS. Isoelectric focusing together with affinity-mediated immunoblot were found to be superior to enzyme-linked immunosorbent assay and Western blot in providing information not only about the antigen specificity of locally produced antibodies but also about their clonal distribution. In 9 of the subjects, HIV-specific oligoclonal bands were demonstrable with higher frequency or intensity in the cerebrospinal fluid than in the autologous serum, indicating autochthonous synthesis of HIV-related antibodies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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