| Autor: |
Rotov KA; Volgograd Antiplague Institute, Russian Agency for Health and Consumer Rights, Russia. vari2@sprint-v.com.ru, Tikhonov SN, Alekseev VV, Snatenkov EA |
| Jazyk: |
English; Russian |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Aug; Vol. 153 (4), pp. 475-7. |
| DOI: |
10.1007/s10517-012-1744-2 |
| Abstrakt: |
We present data on pharmacokinetics of free and liposomal forms of gentamicin. Comparative study of two drug forms showed that immobilization of gentamicin in liposomes significantly increased most important pharmacokinetic parameters of the antibiotic (AUC, Cmax, MRTpo, T(1/2), Kel, Vzpo) and reduced Clpo and Kel. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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