Cell adhesion: a FERM grasp of the tail sorts out integrins.
| Autor: | Brahme NN; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066, USA., Calderwood DA |
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| Jazyk: | angličtina |
| Zdroj: | Current biology : CB [Curr Biol] 2012 Sep 11; Vol. 22 (17), pp. R692-4. |
| DOI: | 10.1016/j.cub.2012.07.049 |
| Abstrakt: | As well as modulating integrin activation, a conserved NPxY motif in integrin cytoplasmic tails that binds the FERM-domain-containing proteins kindlin and sorting nexin 17 plays pivotal roles in integrin recycling and degradation. (Copyright © 2012 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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