Azo-propofols: photochromic potentiators of GABA(A) receptors.
| Autor: | Stein M; Department of Chemistry, Ludwig-Maximilians-Universität, München and Center of Integrated Protein Science, 81377 Munich, Germany., Middendorp SJ, Carta V, Pejo E, Raines DE, Forman SA, Sigel E, Trauner D |
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| Jazyk: | angličtina |
| Zdroj: | Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2012 Oct 15; Vol. 51 (42), pp. 10500-4. Date of Electronic Publication: 2012 Sep 11. |
| DOI: | 10.1002/anie.201205475 |
| Abstrakt: | Shine and rise! GABA(A) receptors are ligand-gated chloride ion channels that respond to γ-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter of the mammalian central nervous system. Azobenzene derivatives of propofol, such as compound 1 (see scheme), increase GABA-induced currents in the dark form and lose this property upon light exposure and thus function as photochromic potentiators. Compound 1 can be employed as a light-dependent general anesthetic in translucent tadpoles. (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.) |
| Databáze: | MEDLINE |
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