Iron-catalyzed cross-coupling of N-heterocyclic chlorides and bromides with arylmagnesium reagents.

Autor: Kuzmina OM; Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany., Steib AK, Flubacher D, Knochel P
Jazyk: angličtina
Zdroj: Organic letters [Org Lett] 2012 Sep 21; Vol. 14 (18), pp. 4818-21. Date of Electronic Publication: 2012 Sep 11.
DOI: 10.1021/ol302136c
Abstrakt: A simple, practical iron salt catalyzed procedure allows fast cross-couplings of N-heterocyclic chlorides and bromides with various electron-rich and -poor arylmagnesium reagents. A solvent mixture of THF and tBuOMe is found to be essential for achieving high yields mainly by avoiding homocoupling side reactions.
Databáze: MEDLINE