An efficient one-pot synthesis and photoinduced DNA cleavage studies of 2-chloro-3-(5-aryl-4,5-dihydroisoxazol-3-yl)quinolines.
| Autor: | Bindu PJ; Department of Studies and Research in Chemistry, Kuvempu University, Shankaraghatt 577 451, India. bindu12_naik@rediffmail.com, Mahadevan KM, Ravikumar Naik TR |
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| Jazyk: | angličtina |
| Zdroj: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Oct 01; Vol. 22 (19), pp. 6095-8. Date of Electronic Publication: 2012 Aug 17. |
| DOI: | 10.1016/j.bmcl.2012.08.034 |
| Abstrakt: | 4,5-Dihydroisoxazoles continue to attract considerable interest due to their wide spread biological activities. Here, we identify an efficient protocol for the preparation of 4,5-dihydroisoxazoles (2-isaxazolines) (4a-g) from quinolinyl chalcones. The nucleolytic activities of synthesized compounds were investigated by agarose gel electrophoresis. All these compounds were showed the remarkable DNA cleavage activity (concentration dependent) with pUC19 DNA at 365nm UV light. The DNA cleavage activity was significantly enhanced by the presence of iminyl and carboxy radicals of DIQ. (Copyright © 2012 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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